Novocaine introduces us to Nathan Caine, a bank executive with a rare disorder—congenital insensitivity to pain (CIP). This condition renders him unable to feel physical pain, a trait that becomes both a blessing and a curse when his girlfriend and coworker is taken hostage during a bank robbery. Nathan must navigate a treacherous path, leveraging his unique condition to rescue her, all while confronting the psychological and moral dilemmas that arise from his inability to feel pain.